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Frequently Asked Questions
All compounds were synthesized using a panel of human glycosyltransferases. The advantage of human glycosyltransferases over their bacterial counterparts is that they do not have off-target activity, i.e., a monosaccharide is added to an acceptor at a single location. After a target has been prepared, it was purified using multi-dimensional chromatography, specifically C18 and HILIC. Incorporation of the six 13C atoms was confirmed via high-resolution mass (Bruker Solarix XR FTICR or Bruker Impact II Q-TOF) and 13C NMR. Glycoform purity was interrogated using LC-MS analysis of a procainamide labeled derivative.